Against the backdrop of corporate behemoths announcing mergers that, they say, are sure to shake up health care – from the Amazon, Berkshire Hathaway, and JPMorgan Chase venture, to the CVS-Aetna deal, to the Humana-Walgreens partnership, and more. But while these superpower alliances are making a splash in the headlines, will they actually be able to disrupt, and save, U.S. health care? Proponents argue that the bargaining power and data competencies of these retailers will squeeze middlemen out of an inefficient supply chain and bring more transparency to health care pricing. But others argue that the promise of these novel efforts is overstated or misguided, particularly because U.S. health care is so complex and deeply rooted. Will consumer-focused models and employer-led initiatives lead to better and less expensive outcomes?